Elevated expression of PDGF-C in coxsackievirus B3-induced chronic myocarditis
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چکیده
منابع مشابه
Elevated expression of PDGF-C in coxsackievirus B3-induced chronic myocarditis.
AIMS Coxsackievirus B3 (CVB3) is a frequent cause of human chronic myocarditis and subsequent fibrosis, leading to dilated cardiomyopathy. The molecular processes underlying the development of fibrosis are poorly understood. Enhanced levels of platelet-derived growth factors (PDGFs), especially PDGF-C, have recently been linked with the development of different forms of fibrosis. Therefore, the...
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Coxsackievirus B3 (CVB3) is the most common causative agent of myocarditis. Acute myocarditis caused by CVB3 infection either recovers completely without any functional and morphological defects or progresses to chronic myocarditis, which is characterized by chronic inflammation and interstitial hyperplasia that may be related to progressive intrinsic dysfunction, degeneration, and loss of card...
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AIMS Coxsackievirus B3 (CVB3)-induced chronic myocarditis in mice is accompanied by severe fibrosis and by sustained elevation of platelet-derived growth factor (PDGF)-A, -B, and -C levels in the cardiac tissue. To test if PDGF stimulation of resident fibroblasts causally contributes to fibrosis, we employed inhibition of PDGF receptor signalling with the orally available kinase inhibitor Imati...
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Backgrounds and Aims: Coxsakievirus B3 (CVB3), one of the six Coxsakievirus B serotypes, is a member of the Enterovirus genus within the Picornaviridae family. CVB3 is an important pathogen of viral myocarditis, which accounts for more than 50% of viral myocarditis cases. The genome of CVB3, like that of other Entroviruses, is a single-stranded, sense, polyadenylated RNA molecule with 7400 nucl...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2005
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/ehi168